An MDMA trial participant told his story: “I understand what happiness is now”


“No matter what happened in my life, I never really felt happy,” he said. “I always feel upset, always feel this kind of latent heaviness. It’s just that there is no connection in my mind. It’s like someone took a cable and unplugged it, and I was trying to put it Plug it back in.”

In the end, Nathan heard about a study testing the use of MDMA to treat severe PTSD and successfully entered a phase 3 clinical trial, which was the last hurdle before US regulatory agencies consider whether to approve the therapy.

Ecstasy It is a synthetic psychoactive substance known as a party drug popular among club members-you may know it as ecstasy, E or Molly. It causes the brain to release a large amount of chemical serotonin, which produces euphoria, but it has also been found to reduce the activity of the limbic system that controls our emotional response. This seems to help people with PTSD re-examine their traumatic experiences during treatment without being overwhelmed by strong emotions such as fear, embarrassment or sadness.

To test this theory, Multidisciplinary Association for Psychedelic Research, A non-profit organization based in California, set up a randomized, double-blind trial-Nathan participated in a trial. Participants participated in three 8-hour meetings and before discussing their problems and accepting, they were given a placebo or two doses of MDMA from two qualified therapists for consultation.

In May 2021, the trial The results are published in “Natural Medicine”. They are breathtaking. Among the 90 participating patients, those who received MDMA reported significantly better results than other patients. After two months of treatment, 67% of participants in the MDMA group no longer had PTSD, compared to 32% in the placebo group.

I think life is something that needs to be explored and appreciated, not something that needs to be endured.

Nathan McGee

Ben CesarA British researcher involved in opening the country’s first psychedelic treatment clinic in Bristol said that the US Food and Drug Administration may approve MDMA-assisted psychotherapy for PTSD before the end of 2023.

Other trials are underway in the United States, the United Kingdom, and elsewhere to test whether the compound resembles Psilocybin and ketamine can similarly be used to help treat mental illnessThe early signs are positive, and if they are confirmed, they may shake the world of mental health treatment.

Nathan and I talked about the experience of MDMA adjuvant therapy. For clarity, our conversation has been compressed and edited.

Q: How does your mental health struggle manifest itself?

A: Before I participated in the trial, my condition was not good. Everything I am trying is very bad. No effect. I tried many different therapists and different techniques. I lost my job in January 2018. It was frustrating. I was unemployed before, but this time it was different. I decided that if it was caused by my mental health, I would solve the problem. I will do it at all costs. If my therapist told me that I had to take off my clothes and walk through a crowded mall, it would help me, I would do it.

Q: How did you get in touch with this research?

A: I’m just in the internet rabbit hole late at night. I have been researching PTSD for several hours, and then I stumbled upon this research. I think I might as well apply directly. I didn’t think about anything. In fact, I later forgot. I didn’t even tell my wife. Then, two months later, I received a call from them and asked if they could interview me.

Q: Take me to learn about the experience of these meetings.

A: When you get there, it really looks like an office building. From the outside, you will never know that a group of people are taking ecstasy. But if you pass, you will be taken to the treatment room, where there are sofas, bedding, blankets and pillows. There is music playing, which is an integral part of the whole experience. It is very calm. It almost feels like a spa. There is plenty of sunshine, and trees and canals can be seen through the windows. It is very peaceful. Then two therapists came in. They check your vital signs-your body temperature, your blood pressure, your heart rate, etc. They chatted with you about what you hope to gain from today’s experience. Then they do this little ritual or ritual, where they light a candle to signify that things have started. It almost feels a bit like a religious or spiritual experience. So they lit the candles, and then a therapist came back with a small plate with pills on it. They give you a glass of water, you drink the water, swallow the pill, and then you sit and wait. Chat while you are waiting.

Once I said, “I don’t think it’s ecstasy.” I’ve never eaten anything like this before, and to be honest, I’m a little nervous. They won’t tell you if you have ecstasy, but the chief therapist told me that almost everyone knows. It started almost when I said I thought I had not accepted it. I mean, I know.


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